Side-to-side slippage of myocytes participates in ventricular wall remodeling acutely after myocardial infarction in rats.
نویسندگان
چکیده
منابع مشابه
Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats.
We investigated the role of cardiomyocyte apoptosis in the remodeling of the left ventricle from 24 h to 12 wk after myocardial infarction in the rat. Infarct size planimetry, quantification of cardiomyocyte apoptosis, terminal deoxynucleotide transferase-mediated dUTP nick-end labeling (TUNEL) methodology, and echocardiography (left ventricular diastolic diameter and ejection fraction) were pe...
متن کاملPatterns of Ventricular Remodeling After Myocardial Infarction
Since the early 1980s, we have learned much about left ventricular (LV) morphologic change in patients after myocardial infarction (MI) and the relationship of such findings to subsequent clinical course (1–5). Left ventricular end-systolic and enddiastolic volumes are effective metrics for the severity of post-MI remodeling, and their changes are closely linked with clinical outcomes. Within b...
متن کاملPossible involvement of apoptotic death of myocytes in left ventricular remodeling after myocardial infarction.
Pathophysiological roles of apoptosis in post-infarction left ventricular (LV) remodeling have not been well characterized. This study showed that TUNEL- or cleaved caspase-3-positive myocytes were identified late after ligation of the left coronary artery in rats, suggesting that apoptotic myocyte death contributed to the morphological change associated with LV remodeling.
متن کامل[Left ventricular remodeling after myocardial infarction].
Left ventricular remodeling describes a number of geometric and structural changes that the left ventricle undergoes after myocardial infarction. Briefly, it comprises expansion of the infarct and dilatation of the healthy left ventricular segments. Its severity is related to the infarct size. These changes in ventricular geometry, in particular the dilatation, influence the long-term incidence...
متن کاملVentricular remodeling after acute myocardial infarction.
The term ventricular remodeling has been coined to describe the geometrical changes in size and shape of the left ventricle occurring after large myocardial infarcts. We do not exactly know what initiates this process. Slipping of myofilaments following destruction of connective tissue--probably due to metalloproteinase activation--could be the initial event. As a consequence, wall stress is in...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1990
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.67.1.23